N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Base Information

Chemical Name:N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid
CAS No.:383372-63-2
Molecular Formula:C₃₃H₂₄N₂O₈
Molecular Weight:576.562
Hs Code.:

<i>N</i>-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3<i>H</i>-xanthen-9-yl)-isophthalamic acid

Synonyms:N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Suppliers and Price of N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

There total 4 articles about N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 383372-58-5
N-{3-[4-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

: 383372-63-2
N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Guidance literature:: With trifluoroacetic acid;
DOI:10.1081/NCN-100002307

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 383372-63-2
N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / CuI; Pd(PPh₃)4; Et₃N / dimethylformamide / 20 °C

2: 100 percent / aq. NH₄OH / 20 °C

3: 88 percent / DIEA / dimethylsulfoxide / 20 °C

4: 88 percent / aq. TFA

With ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Heck coupling reaction;
DOI:10.1081/NCN-100002307

Reference yield:

: 260397-83-9
2-tert-butoxycarbonylamino-3-{4-[3-(2,2,2-trifluoro-acetylamino)-prop-1-ynyl]-phenyl}-propionic acid

: 383372-63-2
N-{3-[4-(2-amino-2-carboxy-ethyl)-phenyl]-prop-2-ynyl}-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-isophthalamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. NH₄OH / 20 °C

2: 88 percent / DIEA / dimethylsulfoxide / 20 °C

3: 88 percent / aq. TFA

With ammonium hydroxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dimethyl sulfoxide;
DOI:10.1081/NCN-100002307