2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

Base Information

Chemical Name:2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride
CAS No.:1366063-26-4
Molecular Formula:C₁₃H₁₇F₃N₂O₂*ClH
Molecular Weight:326.746
Hs Code.:

Synonyms:2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

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Chemical Property of 2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

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Technology Process of 2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

There total 3 articles about 2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1366063-69-5
tert-butyl {2-[(1-hydroxy-2-methylpropan-2-yl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-carbamate

: 1366063-26-4
2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

Reference yield:

: 1366063-61-7
tert-butyl {2-[(1-hydroxy-2-methylpropan-2-yl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-carbamate

: 1366063-26-4
2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: chiral stationary vinyl silica gel phase based on the selector poly(N-methacryloyl-L-leucine-tert-butylamide); column: 670 mm×40 mm / 2-Methylpentane; ethyl acetate / Resolution of racemate

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; In 1,4-dioxane; 2-Methylpentane; dichloromethane; ethyl acetate;

Reference yield:

: 146621-92-3
2-{[(tert-butoxy)carbonyl]amino}-2-[3-(trifluoromethyl)phenyl]acetic acid

: 1366063-26-4
2-amino-N-(1-hydroxy-2-methylpropan-2-yl)-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 0.33 h / 20 °C

2.1: chiral stationary vinyl silica gel phase based on the selector poly(N-methacryloyl-L-leucine-tert-butylamide); column: 670 mm×40 mm / 2-Methylpentane; ethyl acetate / Resolution of racemate

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; 2-Methylpentane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;