Technology Process of 1-benzyloxycarbonyl-6-methoxy-4-quinolone
There total 2 articles about 1-benzyloxycarbonyl-6-methoxy-4-quinolone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-methoxy-4(1H)-quinolinone;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 55 ℃;
for 0.25h;
Inert atmosphere;
Schlenk technique;
benzyl chloroformate;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 21h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.201906237
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2 h / 110 °C / Inert atmosphere; Schlenk technique
1.2: 2 h / 110 °C / Inert atmosphere; Schlenk technique
1.3: 1 h / 250 °C / Inert atmosphere; Schlenk technique
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / 55 °C / Inert atmosphere; Schlenk technique
2.2: 21 h / 20 °C / Inert atmosphere; Schlenk technique
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
DOI:10.1002/anie.201906237
- Guidance literature:
-
1-benzyloxycarbonyl-6-methoxy-4-quinolone;
With
copper(I) bromide dimethylsulfide complex; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane;
In
dichloromethane;
at 18 - 25 ℃;
for 0.333333h;
Inert atmosphere;
Schlenk technique;
ethylmagnesium bromide;
In
dichloromethane;
at 18 - 25 ℃;
for 0.583333h;
enantioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.201906237
