[3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid

Base Information

• Chemical Name: [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid
• CAS No.: 948317-73-5
• Molecular Formula: C₁₁H₁₇NO₉P₂
• Molecular Weight: 369.205
• Mol file: 948317-73-5.mol

Synonyms:[3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid

Chemical Property of [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid

There total 3 articles about [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-[(phenylmethoxy)carbonyl]-β-alanine chloride (51513-97-4) → [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid (948317-73-5)

Guidance literature:

With tris(trimethylsilyl) phosphite; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200601067

Reference yield:

pamidronate (40391-99-9) + phenyl chloroformate (1885-14-9) → [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid (948317-73-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran-water;

Reference yield:

3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) → [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid (948317-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / oxalyl chloride / CH₂Cl₂ / 6 h / 20 °C

2: 98 percent / tris(trimethylsilyl) phosphite / 2 h / 20 °C

With oxalyl dichloride; tris(trimethylsilyl) phosphite; In dichloromethane;

DOI:10.1002/ejoc.200601067

upstream raw materials:

N-[(phenylmethoxy)carbonyl]-β-alanine chloride

3-(benzyloxycarbonylamino)propanoic acid

pamidronate

phenyl chloroformate

Downstream raw materials:

pamidronate