(E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide

Base Information

Chemical Name:(E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide
CAS No.:1421606-71-4
Molecular Formula:C₂₂H₂₁ClN₂O₅
Molecular Weight:428.872
Hs Code.:

Synonyms:(E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide

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Chemical Property of (E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide

Chemical Property:

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Technology Process of (E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide

There total 6 articles about (E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1421606-57-6
8-chloro-4-methoxyquinoline-2-carboxamide

: (E)-5-(2-Iodovinyl)-1,2,3-trimethoxybenzene

: 1421606-71-4
(E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide

Guidance literature:: With copper(I) oxide; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; at 85 ℃; Inert atmosphere;
DOI:10.1021/jo3025626

Reference yield:

: 96876-91-4
N-(o-Chlorphenyl)-aminofumarsaeureethylester

: 1421606-71-4
(E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: polyphosphoric acid / neat (no solvent) / 2 h / 135 °C

2: potassium carbonate / N,N-dimethyl-formamide

3: ammonium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C

4: caesium carbonate; copper(I) oxide; N,N`-dimethylethylenediamine / tetrahydrofuran / 85 °C / Inert atmosphere

With copper(I) oxide; ammonium hydroxide; water; potassium carbonate; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4: |Goldberg Reaction;
DOI:10.1021/jo3025626

Reference yield:

: 95-51-2
o-chloroaniline

: 1421606-71-4
(E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 4 h / 20 °C

2: polyphosphoric acid / neat (no solvent) / 2 h / 135 °C

3: potassium carbonate / N,N-dimethyl-formamide

4: ammonium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C

5: caesium carbonate; copper(I) oxide; N,N`-dimethylethylenediamine / tetrahydrofuran / 85 °C / Inert atmosphere

With copper(I) oxide; ammonium hydroxide; water; potassium carbonate; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: |Michael Addition / 5: |Goldberg Reaction;
DOI:10.1021/jo3025626