1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone

Base Information

Chemical Name:1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone
CAS No.:1142232-45-8
Molecular Formula:C₁₈H₂₀FNO₃
Molecular Weight:317.36
Hs Code.:

Synonyms:1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone

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Chemical Property of 1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone

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Technology Process of 1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone

There total 5 articles about 1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1142232-41-4
methyl 2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)benzoate

: 594-19-4
tert.-butyl lithium

: 1142232-45-8
1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone

Guidance literature:: methyl 2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)benzoate; tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 377082-05-8
dimethyl 4-trifluoromethanesulfonyl-oxy-1,3-benzenedicarboxylate

: 1142232-45-8
1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 17 h / 23 - 90 °C / Inert atmosphere

2: potassium hydroxide / tetrahydrofuran; methanol / 17 h / 0 - 20 °C / Inert atmosphere

3: borane-THF / tetrahydrofuran / 46 h / 23 °C / Inert atmosphere

4: tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ml4005123

Reference yield:

: 5985-24-0
dimethyl 4-hydroxyisophthalate

: 1142232-45-8
1-(2-(5-fluoro-2-(methyloxy)-4-pyridinyl)-5-(hydroxymethyl)phenyl)-2,2-dimethyl-1-propanone

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; dmap / dichloromethane / 24 h / 20 - 23 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 17 h / 23 - 90 °C / Inert atmosphere

3: potassium hydroxide / tetrahydrofuran; methanol / 17 h / 0 - 20 °C / Inert atmosphere

4: borane-THF / tetrahydrofuran / 46 h / 23 °C / Inert atmosphere

5: tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ml4005123