(R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine

Base Information

• Chemical Name: (R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine
• CAS No.: 1142232-56-1
• Molecular Formula: C₂₅H₃₈FNO₃Si
• Molecular Weight: 447.666

Synonyms:(R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine

Chemical Property of (R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine

There total 9 articles about (R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol (1142232-50-5) + methyl iodide (74-88-4) → (R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine (1142232-56-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 23 - 50 ℃; for 15h; Inert atmosphere;

DOI:10.1021/ml4005123

Reference yield:

dimethyl 4-(5-fluoro-2-(methyloxy)-4-pyridinyl)-1,3-benzenedicarboxylate (1142232-39-0) → (R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine (1142232-56-1)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium hydroxide / tetrahydrofuran; methanol / 17 h / 0 - 20 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 46 h / 23 °C / Inert atmosphere

3: tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

5: Chiracel-OD / hexane / Inert atmosphere; Resolution of racemate

6: triethylamine; dmap / dichloromethane / 24 h / 23 °C / Inert atmosphere

7: sodium hydride / N,N-dimethyl-formamide / 15 h / 23 - 50 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; borane-THF; sodium hydride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; pentane;

DOI:10.1021/ml4005123

Reference yield:

dimethyl 4-trifluoromethanesulfonyl-oxy-1,3-benzenedicarboxylate (377082-05-8) → (R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine (1142232-56-1)

Guidance literature:

Multi-step reaction with 8 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 17 h / 23 - 90 °C / Inert atmosphere

2: potassium hydroxide / tetrahydrofuran; methanol / 17 h / 0 - 20 °C / Inert atmosphere

3: borane-THF / tetrahydrofuran / 46 h / 23 °C / Inert atmosphere

4: tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

5: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

6: Chiracel-OD / hexane / Inert atmosphere; Resolution of racemate

7: triethylamine; dmap / dichloromethane / 24 h / 23 °C / Inert atmosphere

8: sodium hydride / N,N-dimethyl-formamide / 15 h / 23 - 50 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium hydride; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; pentane;

DOI:10.1021/ml4005123

upstream raw materials:

dimethyl 4-hydroxyisophthalate

dimethyl 4-trifluoromethanesulfonyl-oxy-1,3-benzenedicarboxylate

dimethyl 4-(5-fluoro-2-(methyloxy)-4-pyridinyl)-1,3-benzenedicarboxylate

4-(5-fluoro-2-(methyloxy)-4-pyridinyl)-3-((methyloxy)carbonyl)benzoic acid

Downstream raw materials:

(R)-(4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl)methanol

(R)-4-(4-(bromomethyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine

(S)-methyl 3-cyclopropyl-3-(2-((4-(5-fluoro-2-methoxypyridin-4-yl)-3-((R)-1-methoxy-2,2-dimethylpropyl)benzyl)oxy)pyridin-4-yl)propanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1142232-56-1 (R)-4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-(1-methoxy-2,2-dimethylpropyl)phenyl)-5-fluoro-2-methoxypyridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send