(1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide

Base Information

Chemical Name:(1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide
CAS No.:1314933-40-8
Molecular Formula:C₂₀H₂₃NO₃
Molecular Weight:325.408
Hs Code.:

Synonyms:(1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide

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Technology Process of (1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide

There total 4 articles about (1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: trans-2-(3-methoxymethoxyphenyl)cyclopropanecarboxylic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1314933-39-5
(1S,2S)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide

: 1314933-40-8
(1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 13h;
DOI:10.1016/j.bmc.2010.12.024

Reference yield:

: 1196052-81-9
methyl trans-3-(3-methoxymethoxyphenyl)propenoate

: 1314933-40-8
(1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C

1.2: 6 h / 20 °C

1.3: pH 4

2.1: potassium hydroxide / methanol / 0 - 20 °C

2.2: pH 1

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 13 h / 20 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 1.2: Corey-Chaykovsky reaction;
DOI:10.1016/j.bmc.2010.12.024

Reference yield:

: methyl trans-2-(3-methoxymethoxyphenyl)cyclopropanecarboxylate

: 1314933-40-8
(1R,2R)-2-(3-(methoxymethoxy)phenyl)-N-((S)-1-phenylethyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 0 - 20 °C

1.2: pH 1

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 13 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.024