methyl trans-3-(3-methoxymethoxyphenyl)propenoate

Base Information

• Chemical Name: methyl trans-3-(3-methoxymethoxyphenyl)propenoate
• CAS No.: 1196052-81-9
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 1196052-81-9.mol

Synonyms:methyl trans-3-(3-methoxymethoxyphenyl)propenoate

Chemical Property of methyl trans-3-(3-methoxymethoxyphenyl)propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl trans-3-(3-methoxymethoxyphenyl)propenoate

There total 2 articles about methyl trans-3-(3-methoxymethoxyphenyl)propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

trans-3-(3-hydroxyphenyl)acrylic acid methyl ester (66417-46-7) + chloromethyl methyl ether (107-30-2) → methyl trans-3-(3-methoxymethoxyphenyl)propenoate (1196052-81-9)

Guidance literature:

trans-3-(3-hydroxyphenyl)acrylic acid methyl ester; With potassium carbonate; In acetone; at 20 ℃; for 0.333333h;

chloromethyl methyl ether; In acetone; at 20 ℃; for 12h;

DOI:10.1021/ja907055q

Reference yield:

3-hydroxy-trans-cinnamic acid (14755-02-3,588-30-7) → methyl trans-3-(3-methoxymethoxyphenyl)propenoate (1196052-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 0 °C / Reflux

2.1: potassium carbonate / acetone / 0.25 h / 20 °C

2.2: 12 h / 20 °C

With sulfuric acid; potassium carbonate; In acetone;

DOI:10.1016/j.bmc.2010.12.024

Reference yield: 23.0%

methyl trans-3-(3-methoxymethoxyphenyl)propenoate (1196052-81-9) + trimethylsulfoxonium iodide (1774-47-6) → methyl trans-2-(3-methoxymethoxyphenyl)cyclopropanecarboxylate

Guidance literature:

trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 1h;

methyl trans-3-(3-methoxymethoxyphenyl)propenoate; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 4h;

DOI:10.1021/ja907055q

upstream raw materials:

trans-3-(3-hydroxyphenyl)acrylic acid methyl ester

chloromethyl methyl ether

3-hydroxy-trans-cinnamic acid

Downstream raw materials:

(1S,2S)-2-(3-(methoxymethoxy)phenyl)cyclopropanecarboxylic acid

tert-butyl ((1S,2R)-2-(3-((S)-3-benzamido-4-(benzylamino)-4-oxobutoxy)phenyl)cyclopropyl)carbamate