N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline

Base Information

Chemical Name:N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline
CAS No.:1301189-27-4
Molecular Formula:C₁₆H₂₁N₃O₄
Molecular Weight:319.36
Hs Code.:

Synonyms:N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline

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Chemical Property of N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline

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Technology Process of N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline

There total 4 articles about N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₇N₃O₃*(x)ClH

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1301189-27-4
N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline

Guidance literature:: C₁₂H₁₇N₃O₃*(x)ClH; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

cyclopropanecarboxylic acid chloride; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1301189-27-4
N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / pyridine; copper(l) iodide / 100 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

3.2: 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; pyridine; copper(l) iodide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 132945-76-7
tert-butyl (3R)-3-cyano-1-pyrrolidinecarboxylate

: 1301189-27-4
N-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-(methyloxy)-2-nitroaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / ethanol; water / 3102.97 Torr

2.1: potassium carbonate / pyridine; copper(l) iodide / 100 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.2: 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; pyridine; copper(l) iodide; In 1,4-dioxane; ethanol; dichloromethane; water;