tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

Base Information

Chemical Name:tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate
CAS No.:1443103-66-9
Molecular Formula:C₂₁H₂₆F₃N₃O₄
Molecular Weight:441.45
Hs Code.:

Synonyms:tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

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Chemical Property of tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

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Technology Process of tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

There total 6 articles about tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101066-87-9
4-iodo-2-(trifluoromethyl)benzonitrile

: 1443103-65-8
tert-butyl (8-amino-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

: 1443103-66-9
tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 20 - 45 ℃; for 16h; Inert atmosphere;

Reference yield:

: (±)-trans-7-amino-1,4-dioxaspiro[4.5]decan-8-ol

: 1443103-66-9
tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h / 0 - 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 3102.97 Torr

5: triethylamine / dimethyl sulfoxide / 16 h / 20 - 45 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 1443103-63-6
(±)-trans-tert-butyl 8-oxo-1,4-dioxaspiro[4.5]decan-7-ylcarbamate

: 1443103-66-9
tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 3102.97 Torr

3: triethylamine / dimethyl sulfoxide / 16 h / 20 - 45 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In methanol; dimethyl sulfoxide; 1,2-dichloro-ethane;