4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile
CAS No.:1443103-85-2
Molecular Formula:C₁₈H₁₈F₃N₃O₃
Molecular Weight:381.354
Hs Code.:

Synonyms:4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile

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Technology Process of 4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile

There total 8 articles about 4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443103-68-1
4-(2-oxohexahydrospiro[benzo[d]imidazole-5,2′-[1,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile

: 74-88-4
methyl iodide

: 1443103-85-2
4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: 4-(2-oxohexahydrospiro[benzo[d]imidazole-5,2′-[1,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

methyl iodide; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 1443103-65-8
tert-butyl (8-amino-1,4-dioxaspiro[4.5]decan-7-yl)carbamate

: 1443103-85-2
4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dimethyl sulfoxide / 16 h / 20 - 45 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

4.2: 1 h / 0 °C

With sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: (±)trans-tert-butyl-8-hydroxy-(1,4-dioxaspiro[4.5]decan-7-yl)carbamate

: 1443103-85-2
4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h / 0 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 3102.97 Torr

4.1: triethylamine / dimethyl sulfoxide / 16 h / 20 - 45 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

7.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

7.2: 1 h / 0 °C

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;