(S)-1-[4-(1-[⁽¹⁸⁾F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Base Information

• Chemical Name: (S)-1-[4-(1-[⁽¹⁸⁾F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
• CAS No.: 1160524-60-6
• Molecular Formula: C₂₃H₂₅FN₂O₆S
• Molecular Weight: 475.527

Synonyms:(S)-1-[4-(1-[⁽¹⁸⁾F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Chemical Property of (S)-1-[4-(1-[⁽¹⁸⁾F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

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Technology Process of (S)-1-[4-(1-[⁽¹⁸⁾F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

There total 1 articles about (S)-1-[4-(1-[⁽¹⁸⁾F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin (1160524-50-4) → (S)-1-[4-(1-[(18)F]fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (1160524-60-6)

Guidance literature:

With [⁽¹⁸⁾F]Et₃N*3HF; In acetonitrile; at 120 ℃; for 0.75h; regioselective reaction;

DOI:10.1021/jm8015014

upstream raw materials:

(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin

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