((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate

Base Information

• Chemical Name: ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate
• CAS No.: 3249-96-5
• Molecular Formula: C₂₀H₁₉ClN₄O₅
• Molecular Weight: 430.848
• Mol file: 3249-96-5.mol

Synonyms:((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate

Chemical Property of ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate

There total 2 articles about ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purine (39824-26-5) + benzoyl chloride (98-88-4) → ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate (3249-96-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2007.02.026

Reference yield:

6-Chloropurine riboside (2004-06-0) → ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate (3249-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / p-TsOH / acetone / 4 h / 20 °C

2: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

With dmap; toluene-4-sulfonic acid; triethylamine; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2007.02.026

Reference yield: 61.0%

((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl benzoate (3249-96-5) → C10H11ClN4O4COC6H4

Guidance literature:

With acetic acid; In water; at 60 ℃; for 5h;

DOI:10.1016/j.bmcl.2007.02.026

upstream raw materials:

6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purine

benzoyl chloride

6-Chloropurine riboside