Technology Process of 1-[5-(benzyloxy)-1H-indol-3-yl]-2-(piperidin-4-yl)ethanone
There total 6 articles about 1-[5-(benzyloxy)-1H-indol-3-yl]-2-(piperidin-4-yl)ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 16 h / 20 °C / Cooling with ice
2.1: thionyl chloride / dichloromethane / 4 h / 80 °C / Inert atmosphere
3.1: magnesium; iodine; methyl iodide / diethyl ether / 1 h / 60 °C
3.2: 1.5 h / 0 - 20 °C
4.1: hydrogenchloride / methanol; water / 2.5 h / 80 °C
With
hydrogenchloride; thionyl chloride; iodine; magnesium; sodium hydroxide; methyl iodide;
In
methanol; diethyl ether; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / dichloromethane / 4 h / 80 °C / Inert atmosphere
2.1: magnesium; iodine; methyl iodide / diethyl ether / 1 h / 60 °C
2.2: 1.5 h / 0 - 20 °C
3.1: hydrogenchloride / methanol; water / 2.5 h / 80 °C
With
hydrogenchloride; thionyl chloride; iodine; magnesium; methyl iodide;
In
methanol; diethyl ether; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate; 18-crown-6 ether / acetone / 20 °C
2.1: magnesium; iodine; methyl iodide / diethyl ether / 1 h / 60 °C
2.2: 1.5 h / 0 - 20 °C
3.1: hydrogenchloride / methanol; water / 2.5 h / 80 °C
With
hydrogenchloride; 18-crown-6 ether; iodine; caesium carbonate; magnesium; methyl iodide;
In
methanol; diethyl ether; water; acetone;
