1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole

Base Information

Chemical Name:1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole
CAS No.:364061-40-5
Molecular Formula:C₁₉H₂₉NO₂
Molecular Weight:303.445
Hs Code.:

Synonyms:1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole

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Chemical Property of 1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole

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Technology Process of 1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole

There total 2 articles about 1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13633-36-8
N,N-bis(2-bromoallyl)-4-methylaniline

: 67-64-1
acetone

: 364061-40-5
1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole

Guidance literature:: N,N-bis(2-bromoallyl)-4-methylaniline; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.5h;

In diethyl ether; pentane; at 20 ℃; for 1h;

acetone; In diethyl ether; pentane; at 20 ℃; for 3h; Further stages.;
DOI:10.1002/1521-3765(20010702)7:13<2896::AID-CHEM2896>3.0.CO;2-R

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 364061-40-5
1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / K₂CO₃ / acetonitrile / Heating

2.1: t-BuLi / pentane; diethyl ether / 0.5 h / -78 °C

2.2: pentane; diethyl ether / 1 h / 20 °C

2.3: 0.45 g / pentane; diethyl ether / 3 h / 20 °C

With tert.-butyl lithium; potassium carbonate; In diethyl ether; acetonitrile; pentane;
DOI:10.1002/1521-3765(20010702)7:13<2896::AID-CHEM2896>3.0.CO;2-R

Reference yield:

: 364061-40-5
1,5-Dihydro-3,4-bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)-2H-pyrrole

: 3,4-Bis(2-hydroxy-2-methylpropyl)-1-(4-methylphenyl)pyrrole

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; at 20 ℃; for 6h;
DOI:10.1002/1521-3765(20010702)7:13<2896::AID-CHEM2896>3.0.CO;2-R