[(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester

Base Information

Chemical Name:[(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester
CAS No.:196938-89-3
Molecular Formula:C₃₁H₄₅N₅O₁₂
Molecular Weight:679.725
Hs Code.:

Synonyms:[(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester

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Chemical Property of [(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester

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Technology Process of [(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester

There total 16 articles about [(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 196938-88-2
Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester

: 196938-89-3
[(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 12h; Ambient temperature;

Reference yield:

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 196938-89-3
[(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / diethyl ether / 0.5 h / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

3: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

4: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.42 h / Ambient temperature

5: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

6: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

7: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

8: 100 percent / H₂ / 10percent Pd/C / ethanol / 12 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 196938-89-3
[(2R)-N-(tert-Butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / diethyl ether / 0.5 h / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

3: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

4: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.75 h / Ambient temperature

5: 82 percent / HCl / ethyl acetate / 1.5 h / Ambient temperature

6: 4-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.5 h / Ambient temperature

7: 85 percent / HCl / ethyl acetate / 1.5 h / Ambient temperature

8: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

9: 100 percent / H₂ / 10percent Pd/C / ethanol / 12 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;