Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester

Base Information

Chemical Name:Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester
CAS No.:196938-88-2
Molecular Formula:C₃₈H₅₁N₅O₁₂
Molecular Weight:769.849
Hs Code.:

Synonyms:Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester

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Chemical Property of Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester

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Technology Process of Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester

There total 14 articles about Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 196938-88-2
Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / diethyl ether / 0.5 h / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

3: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

4: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.42 h / Ambient temperature

5: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

6: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

7: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 196938-88-2
Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / diethyl ether / 0.5 h / 0 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

3: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

4: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.75 h / Ambient temperature

5: 82 percent / HCl / ethyl acetate / 1.5 h / Ambient temperature

6: 4-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.5 h / Ambient temperature

7: 85 percent / HCl / ethyl acetate / 1.5 h / Ambient temperature

8: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 80963-12-8
α-Methyl β-benzyl (2R)-N-(tert-butoxycarbonyl)aspartate diester

: 196938-88-2
Benzyl [(2R)-N-(tert-butoxycarbonyl)-α-methyl aspartyl]-β-(2S)-phenylalanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate triester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

2: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

3: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0.42 h / Ambient temperature

4: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / Ambient temperature

5: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

6: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;