N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

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Chemical Name:N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide
CAS No.:1420070-52-5
Molecular Formula:C₂₂H₂₂F₃N₃O
Molecular Weight:401.431
Hs Code.:

Synonyms:N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

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Chemical Property of N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

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Technology Process of N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

There total 3 articles about N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1420070-52-5
N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: With potassium phosphate; copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; at 130 ℃; for 20h; Schlenk technique; Inert atmosphere;

Reference yield: 72.0%

: 1219936-25-0
N-[2-bromo-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

: 824-51-1
6-methyl-1H-pyrrolo<2,3-b>pyridine

: 1420070-52-5
N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; In 1,4-dioxane; at 130 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.08.029

Reference yield:

: C₁₁H₁₂N₂O₂

: 1420070-52-5
N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; methanol / 2 h / 20 °C

2: copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate / 1,4-dioxane / 18 h / 130 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; methanol; potassium phosphate; copper(l) iodide; sodium hydroxide; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2014.08.029