N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

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Chemical Name:N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide
CAS No.:1420070-53-6
Molecular Formula:C₂₂H₂₁BrF₃N₃O
Molecular Weight:480.327
Hs Code.:

Synonyms:N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

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Chemical Property of N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

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Technology Process of N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

There total 4 articles about N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1420070-53-6
N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

Guidance literature:: With 2-tert-butoxy-2-oxoethylzinc chloride; In ethyl acetate; at 20 ℃; for 1.5h;

Reference yield: 78.0%

: 1420070-52-5
N-ethyl-N-[2-(6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

: 1420070-53-6
N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

Guidance literature:: With N-Bromosuccinimide; In ethyl acetate; at 0 ℃; for 1h;
DOI:10.1016/j.bmcl.2014.08.029

Reference yield:

: 824-51-1
6-methyl-1H-pyrrolo<2,3-b>pyridine

: 1420070-53-6
N-[2-(3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate / 1,4-dioxane / 18 h / 130 °C / Inert atmosphere

2: N-Bromosuccinimide / ethyl acetate / 1 h / 0 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; N-Bromosuccinimide; copper(l) iodide; In 1,4-dioxane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.08.029