[4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester

Base Information

• Chemical Name: [4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester
• CAS No.: 867366-78-7
• Molecular Formula: C₁₇H₁₂Cl₂FNO₃
• Molecular Weight: 368.192
• Mol file: 867366-78-7.mol

Synonyms:[4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester

Chemical Property of [4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester

There total 7 articles about [4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl {4-amino-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetate (770719-11-4) → [4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester (867366-78-7)

Guidance literature:

ethyl {4-amino-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetate; With tert.-butylnitrite; copper dichloride; In acetonitrile; at 70 ℃; for 2.5h;

With hydrogenchloride; In water; acetonitrile;

Reference yield:

3,5-dichlorobenzonitrile (6575-00-4) → [4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester (867366-78-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 0 °C

1.2: Cooling with ice

2.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere

2.2: Cooling with ice

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 4 h / 0 - 20 °C

4.3: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

5.2: 0 °C

6.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

7.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

With 2,4,6-trimethyl-pyridine; tert.-butylnitrite; sodium dithionite; sodium hydride; trifluoroacetic acid; copper dichloride; lithium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

3-chloro-5-methoxybenzonitrile (473923-96-5) → [4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester (867366-78-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere

1.2: Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 4 h / 0 - 20 °C

3.3: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

4.2: 0 °C

5.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

6.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

With 2,4,6-trimethyl-pyridine; tert.-butylnitrite; sodium dithionite; sodium hydride; trifluoroacetic acid; copper dichloride; lithium iodide; In tetrahydrofuran; dichloromethane; water; acetonitrile; mineral oil;

upstream raw materials:

ethyl {4-amino-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetate

3,5-dichlorobenzonitrile

3-chloro-5-methoxybenzonitrile

3-chloro-5-hydroxybenzonitrile

Downstream raw materials:

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(1-methyl-1H-imidazol-2-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-(6-chloro-3-((5-(4-chloro-2-ethyl-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile

3-chloro-5-(6-chloro-3-((5-(5-chloro-1-(2-chlorobenzyl)-3-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile