(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate

Base Information

Chemical Name:(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate
CAS No.:219558-31-3
Molecular Formula:C₂₉H₃₄N₂O₅
Molecular Weight:490.599
Hs Code.:

Synonyms:(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate

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Chemical Property of (-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate

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Technology Process of (-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate

There total 19 articles about (-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 219558-21-1
(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(1ξ-hydroxy-2-(1-ethoxyethoxy))ethyl-1H-pyrrolo<2,3-d>carbazole-6-carboxylate

: 219558-31-3
(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate

Guidance literature:: With N-chloro-succinimide; dimethylsulfide; triethylamine; In toluene; at -20 ℃; for 0.5h;
DOI:10.1021/jo9813989

Reference yield:

: 100-52-7
benzaldehyde

: 219558-31-3
(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate

Guidance literature:: Multi-step reaction with 13 steps

1: MgSO₄ / CH₂Cl₂ / 5 h

2: NaBH₄ / methanol / 1 h / 0 °C

3: 28.5 g / Et₃N / CH₂Cl₂ / Ambient temperature

5: 33.1 g / LiCl, H₂O / dimethylformamide / 4 h / 135 °C

6: 97 percent / TMSOTf, Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

7: 84 percent / PhCO₂H, hydroquinone / benzene / 10 h / Heating

8: 87 percent / NH₃ / methanol / 120 h / Ambient temperature

9: DIPEA, trifluoroacetic anhydride / CH₂Cl₂ / 0.67 h / Ambient temperature

10: KBH₄ / ethanol / 4 h / 75 °C

11: 62 percent / K₂OsO₄*2H₂O, KIO₄ / H₂O / 4 h / 0 °C

12: 73 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

13: 94 percent / NCS, Me₂S, Et₃N / toluene / 0.5 h / -20 °C

With sodium tetrahydroborate; potassium osmate(VI); N-chloro-succinimide; n-butyllithium; potassium borohydride; potassium metaperiodate; dimethylsulfide; trimethylsilyl trifluoromethanesulfonate; ammonia; water; magnesium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; hydroquinone; benzoic acid; trifluoroacetic anhydride; lithium chloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jo9813989

Reference yield:

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 219558-31-3
(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-5-(2-(1-ethoxyethoxy)acetyl)-1H-pyrrolo<2,3-d>carbazole-6-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

2: 28.5 g / Et₃N / CH₂Cl₂ / Ambient temperature

4: 33.1 g / LiCl, H₂O / dimethylformamide / 4 h / 135 °C

5: 97 percent / TMSOTf, Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

6: 84 percent / PhCO₂H, hydroquinone / benzene / 10 h / Heating

7: 87 percent / NH₃ / methanol / 120 h / Ambient temperature

8: DIPEA, trifluoroacetic anhydride / CH₂Cl₂ / 0.67 h / Ambient temperature

9: KBH₄ / ethanol / 4 h / 75 °C

10: 62 percent / K₂OsO₄*2H₂O, KIO₄ / H₂O / 4 h / 0 °C

11: 73 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

12: 94 percent / NCS, Me₂S, Et₃N / toluene / 0.5 h / -20 °C

With potassium osmate(VI); N-chloro-succinimide; n-butyllithium; potassium borohydride; potassium metaperiodate; dimethylsulfide; trimethylsilyl trifluoromethanesulfonate; ammonia; water; triethylamine; N-ethyl-N,N-diisopropylamine; hydroquinone; benzoic acid; trifluoroacetic anhydride; lithium chloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jo9813989