(S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester
• CAS No.: 461638-93-7
• Molecular Formula: C₁₅H₁₇NO₃
• Molecular Weight: 259.305
• Mol file: 461638-93-7.mol

Synonyms:(S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester

Chemical Property of (S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester

There total 1 articles about (S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-pentynoic acid (6089-09-4) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → (S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester (461638-93-7)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2015.10.052

Reference yield: 89.0%

1,1′-bis(azido)ferrocene + (S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester (461638-93-7) → Fe[C5H4-C2N3H-(CH2)2-CO-Phe-OMe]2

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; under N2 atm. to suspn. Fe complex and alkyne in water-t-BuOH aq. soln. sodium ascorbate and CuSO4*5H2O was added and stirred at room temp. for 24 h under the exclusion of light; CH2Cl2 was added, org. layer was dried over Na2SO4, filtered and evapd.,flash chromy. on silica (EtOAc - n-hexane);

DOI:10.1021/om800639m

Reference yield: 80.0%

C16H17N5O3S + (S)-2-Pent-4-ynoylamino-3-phenyl-propionic acid methyl ester (461638-93-7) → C31H34N6O6S

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; In dimethyl sulfoxide; at 60 ℃; for 1h;

DOI:10.1016/j.tet.2015.10.052

upstream raw materials:

4-pentynoic acid

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride