7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Base Information

Chemical Name:7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
CAS No.:1197196-50-1
Molecular Formula:C₂₂H₂₅ClN₄O₂
Molecular Weight:412.919
Hs Code.:

Synonyms:7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Suppliers and Price of 7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

There total 7 articles about 7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 1197196-50-1
7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / 20 °C

2: acetic anhydride; nitric acid / 18 h / 20 °C

3: iron; ammonium chloride / water; isopropyl alcohol / 18 h / Reflux

4: acetic acid / water / 18 h / 20 °C

5: sodium hydroxide / methanol; water / 6 h / pH 13 / Reflux

6: trichlorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / Reflux

7: 20 °C

With nitric acid; acetic anhydride; iron; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In methanol; water; isopropyl alcohol; acetonitrile;
DOI:10.1039/c7md00052a

Reference yield:

: C₁₇H₁₈N₂O₅

: 1197196-50-1
7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water / 6 h / pH 13 / Reflux

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / Reflux

3: 20 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In methanol; water; acetonitrile;
DOI:10.1039/c7md00052a

Reference yield:

: 61032-41-5
methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate

: 1197196-50-1
7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: iron; ammonium chloride / water; isopropyl alcohol / 18 h / Reflux

2: acetic acid / water / 18 h / 20 °C

3: sodium hydroxide / methanol; water / 6 h / pH 13 / Reflux

4: trichlorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / Reflux

5: 20 °C

With iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In methanol; water; isopropyl alcohol; acetonitrile;
DOI:10.1039/c7md00052a