[1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester
CAS No.:189456-88-0
Molecular Formula:C₃₆H₄₆N₂O₅
Molecular Weight:586.772
Hs Code.:

[1-benzyl-4-(benzyl-<i>tert</i>-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester

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Chemical Property of [1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester

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Technology Process of [1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester

There total 17 articles about [1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: acetic acid 2-benzenesulfonyl-1-[1-(benzyl-tert-butoxycarbonyl-amino)-2-(4-methoxy-phenyl)-ethyl]-3-tert-butoxycarbonylamino-4-phenyl-butyl ester

: 189456-88-0
[1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 - 20 ℃; for 12h;
DOI:10.1016/S0040-4020(97)00160-9

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 189456-88-0
[1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaBH₄; I₂ / tetrahydrofuran / 18 h / Heating

2.1: 95 percent / tetrahydrofuran; H₂O / 1 h / 20 °C

3.1: 90 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: 83 percent / methanol; tetrahydrofuran / 3 h / 20 °C

5.1: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 20 °C

6.1: n-BuLi / tetrahydrofuran / -78 °C

6.2: MeOH; DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C

7.1: pyridine / CH₂Cl₂ / 12 h / 20 °C

8.1: 0.94 g / Na₂HPO₄; Na-Hg / methanol / 12 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; disodium hydrogenphosphate; n-butyllithium; sodium amalgam; iodine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: Reduction / 2.1: alkoxycarbonylation / 3.1: Tosylation / 4.1: Substitution / 5.1: Oxidation / 6.1: Metallation / 6.2: Addition / 7.1: Acetylation / 8.1: Elimination;
DOI:10.1016/S0040-4020(97)00160-9

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 189456-88-0
[1-benzyl-4-(benzyl-tert-butoxycarbonyl-amino)-5-(4-methoxy-phenyl)-pent-2-enyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 86 percent / tetrahydrofuran; H₂O / 2 h / 20 °C

2.1: 81 percent / LiBH₄ / tetrahydrofuran / 3 h / 20 °C

3.1: 85 percent / sulfur trioxide pyridine complex; Et₃N / dimethylsulfoxide / 1 h / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran / -78 °C

4.2: MeOH; DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.1: pyridine / CH₂Cl₂ / 12 h / 20 °C

6.1: 0.94 g / Na₂HPO₄; Na-Hg / methanol / 12 h / 0 - 20 °C

With pyridine; disodium hydrogenphosphate; lithium borohydride; n-butyllithium; sodium amalgam; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; 1.1: alkoxycarbonylation / 2.1: Reduction / 3.1: Oxidation / 4.1: Metallation / 4.2: Addition / 5.1: Acetylation / 6.1: Elimination;
DOI:10.1016/S0040-4020(97)00160-9