2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid

Base Information

Chemical Name:2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid
CAS No.:1352064-38-0
Molecular Formula:C₂₅H₃₀Cl₂N₂O₅S
Molecular Weight:541.496
Hs Code.:

Synonyms:2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid

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Chemical Property of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid

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Technology Process of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid

There total 5 articles about 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352076-06-2
N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide

: 1352064-38-0
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: With sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; acetonitrile; for 20h;

Reference yield:

: 1352076-03-9
C₃₃H₃₈Cl₂N₂O₂

: 1352064-38-0
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium cerium (IV) nitrate / water; acetonitrile / 48 h / 25 °C

2: lithium hydroxide / dichloromethane; water / 0.08 h / 0 °C / Inert atmosphere

3: pyridine / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere

4: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 36 h / Inert atmosphere

With pyridine; sodium periodate; ammonium cerium (IV) nitrate; ruthenium(III) trichloride hydrate; lithium hydroxide; In tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401753e

Reference yield:

: 1352076-04-0
C₂₅H₃₀Cl₂N₂O

: 1352064-38-0
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(methylsulfonamido)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere

2: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 36 h / Inert atmosphere

With pyridine; sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401753e