N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide

Base Information

Chemical Name:N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide
CAS No.:1352076-06-2
Molecular Formula:C₂₆H₃₂Cl₂N₂O₃S
Molecular Weight:523.524
Hs Code.:

Synonyms:N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide

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Chemical Property of N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide

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Technology Process of N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide

There total 4 articles about N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352076-04-0
C₂₅H₃₀Cl₂N₂O

: 124-63-0
methanesulfonyl chloride

: 1352076-06-2
N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm401753e

Reference yield:

: 1352076-03-9
C₃₃H₃₈Cl₂N₂O₂

: 1352076-06-2
N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium cerium (IV) nitrate / water; acetonitrile / 48 h / 25 °C

2: lithium hydroxide / dichloromethane; water / 0.08 h / 0 °C / Inert atmosphere

3: pyridine / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere

With pyridine; ammonium cerium (IV) nitrate; lithium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401753e

Reference yield:

: 1352075-22-9
(S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanal

: 1352076-06-2
N-((S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 0 - 25 °C / Inert atmosphere

2: ammonium cerium (IV) nitrate / water; acetonitrile / 48 h / 25 °C

3: lithium hydroxide / dichloromethane; water / 0.08 h / 0 °C / Inert atmosphere

4: pyridine / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere

With pyridine; ammonium cerium (IV) nitrate; sodium tris(acetoxy)borohydride; lithium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401753e