6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Base Information

Chemical Name:6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole
CAS No.:142502-13-4
Molecular Formula:C₂₄H₂₅NO₄S
Molecular Weight:423.533
Hs Code.:

Synonyms:6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Suppliers and Price of 6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

There total 1 articles about 6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 131938-81-3
(6aR,7S,10aR)-9-Methyl-6-oxo-5-(toluene-4-sulfonyl)-5,6,6a,7,8,10a-hexahydro-indeno[2,1-b]indole-7-carboxylic acid methyl ester

: 142502-13-4
6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1016/0223-5234(92)90100-F

Reference yield: 99.0%

: 100-39-0
benzyl bromide

: 142502-13-4
6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

: 142502-14-5
7α-benzyloxymethyl-6α-hydroxy-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In benzene; for 0.5h; Ambient temperature;
DOI:10.1016/0223-5234(92)90100-F

Reference yield:

: 142502-13-4
6α-hydroxy-7α-hydroxymethyl-9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

: 142502-08-7
7α-benzyloxymethyl-6β-indol-3'-yl-9-methyl-5,6α,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / n-Bu₄NHSO₄, 50percent NaOH / benzene / 0.5 h / Ambient temperature

2: 91 percent / 4-dimethylaminopyridine (DMAP), Et₃N / CHCl₃ / 1 h / Heating

3: 96 percent / benzene / 0.5 h / Heating

4: 90 percent / 5percent Na-Hg, Na₂HPO₄ / diethyl ether; methanol / 1 h / Ambient temperature

With dmap; sodium hydroxide; disodium hydrogenphosphate; sodium amalgam; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; In methanol; diethyl ether; chloroform; benzene;
DOI:10.1016/0223-5234(92)90100-F