C₄₇H₅₀ClNO₅Si

Base Information

• Chemical Name: C₄₇H₅₀ClNO₅Si
• CAS No.: 1607800-34-9
• Molecular Formula: C₄₇H₅₀ClNO₅Si
• Molecular Weight: 772.456
• Mol file: 1607800-34-9.mol

Synonyms:C₄₇H₅₀ClNO₅Si

Chemical Property of C₄₇H₅₀ClNO₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₅₀ClNO₅Si

There total 11 articles about C₄₇H₅₀ClNO₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C21H24O4Si (1607799-92-7) + C27H30ClNOS (1607800-31-6) → C47H50ClNO5Si (1607800-34-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 31h; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.bmc.2014.03.012

Reference yield:

3-(4-methoxyphenyl)propanoic acid (1929-29-9) → C47H50ClNO5Si (1607800-34-9)

Guidance literature:

Multi-step reaction with 11 steps

1.1: sulfuric acid / 3.5 h / Reflux; Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.33 h / 20 °C / Inert atmosphere

4.1: toluene / 0.33 h / Inert atmosphere; Reflux

5.1: hydrogen; palladium on activated charcoal / ethanol / 10 h / 20 °C / Inert atmosphere

6.1: hydrogen bromide / acetic acid / 3 h / Inert atmosphere; Reflux

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 8 h / 0 - 20 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

9.1: Lawessons reagent / tetrahydrofuran / 0.03 h / Inert atmosphere; Reflux

10.1: potassium carbonate / acetone / 6 h / 20 °C / Inert atmosphere

11.1: dichloromethane / 31 h / 20 °C / Inert atmosphere; Molecular sieve

With Lawessons reagent; dmap; oxalyl dichloride; sulfuric acid; palladium on activated charcoal; hydrogen bromide; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene; 4.1: |Wittig Olefination;

DOI:10.1016/j.bmc.2014.03.012

Reference yield:

methyl 3-(4-methoxyphenyl)propionate (15823-04-8) → C47H50ClNO5Si (1607800-34-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.33 h / 20 °C / Inert atmosphere

3.1: toluene / 0.33 h / Inert atmosphere; Reflux

4.1: hydrogen; palladium on activated charcoal / ethanol / 10 h / 20 °C / Inert atmosphere

5.1: hydrogen bromide / acetic acid / 3 h / Inert atmosphere; Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 8 h / 0 - 20 °C / Inert atmosphere

7.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

8.1: Lawessons reagent / tetrahydrofuran / 0.03 h / Inert atmosphere; Reflux

9.1: potassium carbonate / acetone / 6 h / 20 °C / Inert atmosphere

10.1: dichloromethane / 31 h / 20 °C / Inert atmosphere; Molecular sieve

With Lawessons reagent; dmap; oxalyl dichloride; palladium on activated charcoal; hydrogen bromide; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene; 3.1: |Wittig Olefination;

DOI:10.1016/j.bmc.2014.03.012

upstream raw materials:

3-(4-methoxyphenyl)propanoic acid

methyl 3-(4-methoxyphenyl)propionate

3-(p-methoxyphenyl)-1-propanol

3-(4-methoxyphenyl)propional

Downstream raw materials:

RE₁₄₇