5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide

Base Information

Chemical Name:5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide
CAS No.:1395396-99-2
Molecular Formula:C₂₄H₂₈F₃N₃O₃
Molecular Weight:463.5
Hs Code.:

Synonyms:5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide

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Chemical Property of 5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide

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Technology Process of 5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide

There total 4 articles about 5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: C₂₀H₂₀F₃IN₂O₃

: 1395396-99-2
5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide

Guidance literature:: With potassium carbonate; In acetonitrile; for 4h; Reflux;
DOI:10.1016/j.bmc.2012.06.026

Reference yield:

: 1395396-62-9
5-(2-bromoacetamido)-N-butyl-2-(o-trifluoromethylphenoxy)benzamide

: 1395396-99-2
5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium iodide / acetonitrile / 0.5 h / Reflux

2: potassium carbonate / acetonitrile / 4 h / Reflux

With potassium carbonate; sodium iodide; In acetonitrile;
DOI:10.1016/j.bmc.2012.06.026

Reference yield:

: 444-30-4
2-(trifluoromethyl)phenol

: 1395396-99-2
5-(2-(pyrrolidin-1-yl)acetamido)-2-(2-(trifluoromethyl)phenoxy)-N-butylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 2 h / 70 °C / Cooling with ice; Inert atmosphere

1.2: 4 h / 70 °C / Inert atmosphere

2.1: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; water / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane; water / 3 h / -10 - 20 °C

4.1: sodium iodide / acetonitrile / 0.5 h / Reflux

5.1: potassium carbonate / acetonitrile / 4 h / Reflux

With sodium tetrahydroborate; palladium 10% on activated carbon; sodium hydride; potassium carbonate; triethylamine; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.06.026