(Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

Base Information

Chemical Name:(Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide
CAS No.:1390675-47-4
Molecular Formula:C₂₃H₂₅N₃O₅S₂
Molecular Weight:487.601
Hs Code.:

Synonyms:(Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

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Chemical Property of (Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

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Technology Process of (Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

There total 3 articles about (Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390675-64-5
C₁₆H₁₈N₂O₄S

: 70-55-3
toluene-4-sulfonamide

: 1390675-47-4
(Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2012.05.079

Reference yield:

: 1390675-52-1
C₁₂H₁₁NO₂S₂

: 1390675-47-4
(Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 7 h / 70 - 80 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.05.079

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 1390675-47-4
(Z)-2-(5-(2-methoxybenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate; acetic acid / 10 h / Reflux

2: N-ethyl-N,N-diisopropylamine / ethanol / 2.17 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / ethanol / 7 h / 70 - 80 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With dmap; sodium acetate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; 1: Knoevenagel condensation;
DOI:10.1016/j.bmc.2012.05.079