allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate

Base Information

Chemical Name:allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate
CAS No.:878626-70-1
Molecular Formula:C₃₉H₄₇N₃O₇
Molecular Weight:669.818
Hs Code.:

Synonyms:allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate

Suppliers and Price of allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate

There total 4 articles about allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3S)-3-Methyl-2-[methyl-((S)-2-methylamino-propionyl)-amino]-pentanoic acid allyl ester

: 77128-72-4,201335-88-8
N-(9-fluorenylmethoxycarbonyl)-O-methyl-L-tyrosine

: 878626-70-1
allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol052907d

Reference yield:

: (2S,3S)-allyl 3-methyl-2-(methylamino)pentanoate

: 878626-70-1
allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.47 g / iPr₂NEt; HATU / CH₂Cl₂ / 1.5 h / 20 °C

2: aq. HCl / ethyl acetate / 1 h / 0 °C

3: 2.80 g / iPr₂NEt; HATU / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; ethyl acetate;
DOI:10.1021/ol052907d

Reference yield:

: 878626-90-5
Boc-(N-Me)-Ala-(N-Me)Ile-O-allyl

: 878626-70-1
allyl N-[(S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)-propanoyl]-N-methyl-L-alanyl-N-methyl-L-isoleucinate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / ethyl acetate / 1 h / 0 °C

2: 2.80 g / iPr₂NEt; HATU / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; ethyl acetate;
DOI:10.1021/ol052907d