Fmoc-tyr(ME)-OH

Base Information

• Chemical Name: Fmoc-tyr(ME)-OH
• CAS No.: 77128-72-4
• Molecular Formula: C25H23NO5
• Molecular Weight: 417.461
• Hs Code.: 29242990
• European Community (EC) Number: 812-305-3
• Nikkaji Number: J1.180.828J
• Mol file: 77128-72-4.mol

Synonyms:FMOC-TYR(ME)-OH;77128-72-4;Fmoc-O-methyl-L-tyrosine;Fmoc-4-Methoxy-L-phenylalanine;FMOC-L-4-METHOXYPHE;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxyphenyl)propanoic acid;Fmoc-O-Methyl-Tyr-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-methoxyphenyl)propanoic acid;MFCD00153368;fmoc-(O-methyl)-l-tyrosine;FMOC-4-METHOXY-PHE-OH;SCHEMBL1311051;Fmoc-Tyr(Me)-OH, AldrichCPR;L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-;FMOC-TYR -OH;AC1MC6M4;AC1Q49KJ;Fmoc-L-4-Methoxyphenylalanine;CTK7A2400;KS-00000JOO;FMOC-L-TYR(ME);Fmoc-4-Methoxy-L-Phe-OH;FMOC-L-TYR(ME)-OH;Fmoc-L-tyrosine methyl ether;FMOC-P-METHOXY-PHE-OH;FMOC-PHE(4-OME)-OH;Fmoc-(S)-3-amino-3-(4-methoxyphenyl)propionic acid;FMOC-L-4-MEO-PHE-OH;JYQODLWFOPCSCS-QHCPKHFHSA-N;FMOC-4-METHOXYPHENYLALANINE;N-[(9H-Fluoren-9-Yl-Methoxy)Carbonyl]-O-Methyl-L-Tyrosine;FMOC-L-BETA-PHE(4-OME)-OH;AKOS015837302;AKOS015896041;AM82330;CS-W011659;HY-W010943;(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoic acid;Fmoc-Phe(4-OMe)-OH,Fmoc-Tyr(Me)-OH;AC-25341;AK-48497;PS-12805;(S)-FMOC-4-METHOXY-BETA-PHENYLALANINE;I10336;EN300-3395154;A838965;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-METHYL-L-TYROSINE;(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methoxyphenyl)propanoic acid;(S)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-3-(4-METHOXYPHENYL)PROPANOIC ACID;(s)-3-(4-methoxy-phenyl)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-propionic acid;N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-methyl-L-tyrosine (Fmoc-L-Tyr(Me)-OH)

Chemical Property of Fmoc-tyr(ME)-OH

Chemical Property:

• Vapor Pressure: 1.15E-17mmHg at 25°C
• Melting Point: 161 °C
• Refractive Index: 1.62
• Boiling Point: 647.8 °C at 760 mmHg
• PKA: 2.97±0.10(Predicted)
• Flash Point: 345.6 °C
• PSA: 84.86000
• Density: 1.274 g/cm³
• LogP: 4.62050
• Storage Temp.: Store at 0°C
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 417.15762283
• Heavy Atom Count: 31
• Complexity: 595

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-O-methyl-L-tyrosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Isomeric SMILES: COC1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of Fmoc-tyr(ME)-OH

There total 8 articles about Fmoc-tyr(ME)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Fmoc-Tyr(OMe)-OMe → N-(9-fluorenylmethoxycarbonyl)-O-methyl-L-tyrosine (77128-72-4,201335-88-8)

Guidance literature:

With magnesium iodide; In tetrahydrofuran; at 120 ℃; for 1h; chemoselective reaction; Inert atmosphere; Microwave irradiation; Sealed tube;

DOI:10.1002/chem.201501799

Reference yield: 92.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + O-methyl-L-tyrosine (3308-72-3,6230-11-1,7635-29-2,39878-65-4) → N-(9-Fluorenylmethyloxy)carbonyl-O-methyl-L-tyrosine (77128-72-4,201335-88-8)

Guidance literature:

With sodium carbonate; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)81776-2

Reference yield: 64.0%

(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4'-methoxyphenyl)propionic acid tert-butyl ester (381222-43-1) → N-(9-fluorenylmethoxycarbonyl)-O-methyl-L-tyrosine (77128-72-4,201335-88-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1039/b103832j

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

O-methyl-L-tyrosine

O-Methyltyrosine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4'-methoxyphenyl)propionic acid tert-butyl ester

(S)-2-{[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxy-phenyl)-propionyl]-methyl-amino}-propionic acid benzyl ester

[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester