2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Base Information

Chemical Name:2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide
CAS No.:1301660-39-8
Molecular Formula:C₃₂H₃₂F₇N₃O₃
Molecular Weight:639.613
Hs Code.:

2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Synonyms:2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

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Chemical Property of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

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Technology Process of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

There total 9 articles about 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1301660-93-4
methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-3-pyrrolidinecarboxylate

: 1301660-39-8
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-3-pyrrolidinecarboxylate; With sodium tetrahydroborate; calcium chloride; In methanol; at 0 - 20 ℃;

With hydrogenchloride; In methanol; water;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-39-8
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: acetic acid; iron / ethanol; water / 60 - 75 °C

6.1: dmap; triethylamine / dichloromethane / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

7.2: 1 h / -78 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: calcium chloride; sodium tetrahydroborate / methanol / 0 - 20 °C

With dmap; sodium tetrahydroborate; osmium(VIII) oxide; water; iron; sodium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; calcium chloride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-56-9
2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-formyl-3-pyridinyl]-N,2-dimethylpropanamide

: 1301660-39-8
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-2,2-dimethyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 2 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

3.1: acetic acid; iron / ethanol; water / 60 - 75 °C

4.1: dmap; triethylamine / dichloromethane / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

5.2: 1 h / -78 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: calcium chloride; sodium tetrahydroborate / methanol / 0 - 20 °C

With dmap; sodium tetrahydroborate; iron; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; calcium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;