10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III

Base Information

Chemical Name:10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III
CAS No.:325735-61-3
Molecular Formula:C₄₆H₇₃NO₁₀Si₂
Molecular Weight:856.257
Hs Code.:

Synonyms:10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III

Chemical Property:

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Technology Process of 10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III

There total 13 articles about 10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 110-91-8,99108-56-2
morpholine

: 325735-59-9
10-deacetoxy-10-formyl-7-O-13-O-bis-triethylsilylbaccatin III

: 325735-61-3
10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: With sodium cyanoborohydride; acetic acid; In ethanol; at 20 ℃; for 18h;
DOI:10.3987/COM-00-9051

Reference yield:

: 204764-74-9
10-deacetoxy-10-hydroxypropyl-7-O-triethylsilylbaccatin III

: 325735-61-3
10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 9 steps

1.1: 73 percent / n-Bu₃P / tetrahydrofuran / 2 h / 20 °C

2.1: 81 percent / m-CPBA / tetrahydrofuran / 3 h / 20 °C

3.1: imidazole / dimethylformamide / 2 h / 20 °C

4.1: OsO₄; NMO / tetrahydrofuran; H₂O / 15 h / 20 °C

4.2: NaIO₄ / tetrahydrofuran; methanol; H₂O / 6 h / 20 °C

5.1: 96 percent / NaBH₄ / methanol / 2 h / 0 °C

6.1: 92 percent / n-Bu₃P / tetrahydrofuran / 2 h / 20 °C

7.1: 85 percent / m-CPBA / tetrahydrofuran / 2 h / 20 °C

8.1: OsO₄; NMO / tetrahydrofuran; methanol; H₂O / 18 h

8.2: 96 percent / NaIO₄ / tetrahydrofuran; methanol; H₂O / 13 h / 20 °C

9.1: 85 percent / NaBH₃CN; AcOH / ethanol / 18 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; tributylphosphine; sodium cyanoborohydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-00-9051

Reference yield:

: 994-30-9
triethylsilyl chloride

: 325735-61-3
10-deacetoxy-10-morpholinomethyl-7-O-13-O-bis-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 7 steps

1.1: imidazole / dimethylformamide / 2 h / 20 °C

2.1: OsO₄; NMO / tetrahydrofuran; H₂O / 15 h / 20 °C

2.2: NaIO₄ / tetrahydrofuran; methanol; H₂O / 6 h / 20 °C

3.1: 96 percent / NaBH₄ / methanol / 2 h / 0 °C

4.1: 92 percent / n-Bu₃P / tetrahydrofuran / 2 h / 20 °C

5.1: 85 percent / m-CPBA / tetrahydrofuran / 2 h / 20 °C

6.1: OsO₄; NMO / tetrahydrofuran; methanol; H₂O / 18 h

6.2: 96 percent / NaIO₄ / tetrahydrofuran; methanol; H₂O / 13 h / 20 °C

7.1: 85 percent / NaBH₃CN; AcOH / ethanol / 18 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; tributylphosphine; sodium cyanoborohydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-00-9051