11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal)

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Chemical Name:11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal)
CAS No.:191029-96-6
Molecular Formula:C₃₅H₄₄O₄
Molecular Weight:528.732
Hs Code.:

Synonyms:11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal)

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Chemical Property of 11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal)

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Technology Process of 11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal)

There total 5 articles about 11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 191029-95-5
11,17-bis(4-methoxyphenyl)-18a-homoestra-5,9⁽¹¹⁾,16-trien-3-one cyclic (1,2-ethanediyl acetal)

: 191029-96-6
11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal)

Guidance literature:: With ammonia; lithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1002/prac.19973390164

Reference yield:

: 168131-50-8
18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)

: 191029-96-6
11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal)

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / 2,6-di-tert-butylpyridine / CH₂Cl₂ / Ambient temperature

2: 57 percent / LiCl, 2 M aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / Heating

3: 2,6-di-tert-butylpyridine / CH₂Cl₂ / Ambient temperature

4: 28 percent / LiCl, 2 M aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / Heating

5: 91 percent / Li, liq. NH₃ / tetrahydrofuran / -78 °C

With 2,6-di-tert-butyl-pyridine; ammonia; lithium; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1002/prac.19973390164

Reference yield:

: 191029-90-0
17-{[(trifluoromethyl)sulfonyl]oxy}-18a-homoestra-5,16-diene-3,11-dione cyclic 3-(1,2-ethanediyl acetal)

: 191029-96-6
11β,17β-bis(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic (1,2-ethanediyl acetal)

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / LiCl, 2 M aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / Heating

2: 2,6-di-tert-butylpyridine / CH₂Cl₂ / Ambient temperature

3: 28 percent / LiCl, 2 M aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / Heating

4: 91 percent / Li, liq. NH₃ / tetrahydrofuran / -78 °C

With 2,6-di-tert-butyl-pyridine; ammonia; lithium; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1002/prac.19973390164