(R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide

Base Information

Chemical Name:(R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide
CAS No.:1581755-45-4
Molecular Formula:C₂₅H₂₇FN₂O
Molecular Weight:390.501
Hs Code.:

Synonyms:(R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide

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Chemical Property of (R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide

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Technology Process of (R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide

There total 5 articles about (R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 100-82-3
(3-fluorophenyl)methanamine

: (R)-1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxylic acid

: 1581755-45-4
(R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.chembiol.2021.04.020

Reference yield:

: 15914-84-8,1517-72-2
(S)-1-(1-Naphthyl)ethanol

: 1581755-45-4
(R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride / dichloromethane / 0.67 h / 0 °C

1.2: 16 h / 20 °C

2.1: sodium hydroxide; methanol / 16 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With methanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Methanesulfonic anhydride; In dichloromethane;
DOI:10.1016/j.chembiol.2021.04.020

Reference yield:

: ethyl (R)-1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxylate

: 1581755-45-4
(R)-N-(3-fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; methanol / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With methanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane;
DOI:10.1016/j.chembiol.2021.04.020