3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide

Base Information

Chemical Name:3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide
CAS No.:332046-11-4
Molecular Formula:C₁₉H₁₂BrN₅O₂S
Molecular Weight:454.307
Hs Code.:

Synonyms:3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide

Suppliers and Price of 3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide

There total 3 articles about 3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 2564-02-5
N-(4-bromophenyl)-2-chloroacetamide

: 4-methylmorpholinium 6-amino-3,5-dicyano-4-(furan-2-yl)pyridine-2-thiolate

: 332046-11-4
3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1134/S1070428014120185

Reference yield:

: 123518-02-5
2,6-diamino-4-(furan-2-yl)-4H-thiopyran-3,5-dicarbonitrile

: 2564-02-5
N-(4-bromophenyl)-2-chloroacetamide

: 332046-11-4
3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: 2,6-diamino-4-(furan-2-yl)-4H-thiopyran-3,5-dicarbonitrile; With potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; for 24h;

N-(4-bromophenyl)-2-chloroacetamide; In ethanol; water; N,N-dimethyl-formamide; for 5h;
DOI:10.1134/S1070428018100019

Reference yield:

: 98-01-1
furfural

: 332046-11-4
3,6-diamino-N-(4-bromophenyl)-5-cyano-4-(furan-2-yl)thieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; hydrogen sulfide / ethanol / 10 °C

1.2: 20 °C

2.1: potassium hydroxide / ethanol; N,N-dimethyl-formamide; water / 24 h

2.2: 5 h

With hydrogen sulfide; triethylamine; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1134/S1070428018100019