7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one

Base Information

Chemical Name:7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one
CAS No.:1392119-26-4
Molecular Formula:C₃₃H₃₈O₅Si
Molecular Weight:542.747
Hs Code.:

Synonyms:7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one

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Chemical Property of 7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one

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Technology Process of 7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one

There total 7 articles about 7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1154740-74-5
4,4,5,5-tetramethyl-2-(5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1,3,2-dioxaborolane

: 1392119-25-3
7-benzyloxy-4-bromo-3-(tert-butyldimethylsilanyloxymethyl)isochromen-1-one

: 1392119-26-4
7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one

Guidance literature:: With sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triphenylphosphine; In 1,4-dioxane; water; for 12h; Inert atmosphere; Reflux;

Reference yield:

: 35450-36-3
methyl 2-bromo-5-methoxybenzoate

: 1392119-26-4
7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: boron tribromide / dichloromethane / 24 h / -78 - 0 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 12 h / 20 - 50 °C / Inert atmosphere

4: 1H-imidazole / dichloromethane / 3 h / 20 °C

5: copper(ll) bromide / dicyclohexylamine hydrochloride / 1,2-dichloro-ethane / 2 h / Industry scale; Reflux

6: sodium carbonate / triphenylphosphine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 12 h / Inert atmosphere; Reflux

With 1H-imidazole; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; copper(ll) bromide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; dicyclohexylamine hydrochloride; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 154607-00-8
methyl 3-hydroxy-6-bromobenzoate

: 1392119-26-4
7-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)-4-(5-methylchroman-6-yl)isochromen-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 12 h / 20 - 50 °C / Inert atmosphere

3: 1H-imidazole / dichloromethane / 3 h / 20 °C

4: copper(ll) bromide / dicyclohexylamine hydrochloride / 1,2-dichloro-ethane / 2 h / Industry scale; Reflux

5: sodium carbonate / triphenylphosphine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 12 h / Inert atmosphere; Reflux

With 1H-imidazole; sodium carbonate; potassium carbonate; triethylamine; copper(ll) bromide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; dicyclohexylamine hydrochloride; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;