4-[(4-aminopyrimidine-5-yl)carbonyl]amino-N-(2,6-dichlorobenzoyl)-L-phenylalanine methylester

Base Information

• Chemical Name: 4-[(4-aminopyrimidine-5-yl)carbonyl]amino-N-(2,6-dichlorobenzoyl)-L-phenylalanine methylester
• CAS No.: 857870-02-1
• Molecular Formula: C₂₂H₁₉Cl₂N₅O₄
• Molecular Weight: 488.33
• Mol file: 857870-02-1.mol

Synonyms:4-[(4-aminopyrimidine-5-yl)carbonyl]amino-N-(2,6-dichlorobenzoyl)-L-phenylalanine methylester

Chemical Property of 4-[(4-aminopyrimidine-5-yl)carbonyl]amino-N-(2,6-dichlorobenzoyl)-L-phenylalanine methylester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-[(4-aminopyrimidine-5-yl)carbonyl]amino-N-(2,6-dichlorobenzoyl)-L-phenylalanine methylester

There total 1 articles about 4-[(4-aminopyrimidine-5-yl)carbonyl]amino-N-(2,6-dichlorobenzoyl)-L-phenylalanine methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-pyrimidin-5-carboxylic acid (20737-41-1) + Nα-(2,6-dichlorobenzoyl)-4-amino-L-phenylalanine methyl ester (554419-04-4) → 4-[(4-aminopyrimidine-5-yl)carbonyl]amino-N-(2,6-dichlorobenzoyl)-L-phenylalanine methylester (857870-02-1)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

Reference yield:

4-[(4-aminopyrimidine-5-yl)carbonyl]amino-N-(2,6-dichlorobenzoyl)-L-phenylalanine methylester (857870-02-1) + 1,1'-carbonyldiimidazole (530-62-1) → N-(2,6-dichlorobenzoyl)-4-(2,4-dioxo-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine-3(2H)-yl)-L-phenylalanine methylester (857870-79-2)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 110 ℃; for 24h;

upstream raw materials:

4-amino-pyrimidin-5-carboxylic acid

Nα-(2,6-dichlorobenzoyl)-4-amino-L-phenylalanine methyl ester

Downstream raw materials:

N-(2,6-dichlorobenzoyl)-4-(2,4-dioxo-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine-3(2H)-yl)-L-phenylalanine methylester