2,4-dichloro-N-(1-phenylethyl)aniline

Base Information

• Chemical Name: 2,4-dichloro-N-(1-phenylethyl)aniline
• CAS No.: 1040062-38-1
• Molecular Formula: C₁₄H₁₃Cl₂N
• Molecular Weight: 266.17
• Mol file: 1040062-38-1.mol

Synonyms:2,4-dichloro-N-(1-phenylethyl)aniline

Chemical Property of 2,4-dichloro-N-(1-phenylethyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-N-(1-phenylethyl)aniline

There total 3 articles about 2,4-dichloro-N-(1-phenylethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-phenylethyl 2,2,2-trichloroacetimidate (99421-72-4) + 2,4-Dichloroaniline (554-00-7,51908-09-9) → 2,4-dichloro-N-(1-phenylethyl)aniline (1040062-38-1)

Guidance literature:

With C₂₇H₃₅F₆N₄O₂⁽¹⁺⁾*BF₄^(1-); In dichloromethane; for 4h;

DOI:10.1021/acscatal.1c05296

Reference yield:

2,4-dichloro-N-(1-phenylethylidene)aniline (191340-15-5) → 2,4-dichloro-N-(1-phenylethyl)aniline (1040062-38-1)

Guidance literature:

With lithium aluminium tetrahydride; In toluene; at 0 - 60 ℃; for 3h; Reagent/catalyst; regioselective reaction;

DOI:10.1002/ejoc.201200829

Reference yield:

2,4-Dichloroaniline (554-00-7,51908-09-9) + phenylacetylene (536-74-3) → 2,4-dichloro-N-(1-phenylethyl)aniline (1040062-38-1) + C14H13Cl2N (940367-78-2)

Guidance literature:

2,4-Dichloroaniline; phenylacetylene; With [Ti(bptd)(NMe₂)]; In toluene; at 80 ℃; for 8h;

With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; at 80 ℃; for 3h;

DOI:10.1021/om1010935

upstream raw materials:

2,4-Dichloroaniline

phenylacetylene

2,4-dichloro-N-(1-phenylethylidene)aniline

1-phenylethyl 2,2,2-trichloroacetimidate

Refernces

• 1、 Li, Lei,Huang, Genping,Chen, Zhou,Liu, Wei,Wang, Xiufang,Chen, Yanmei,Yang, Lijuan,Li, Wu,Li, Yahong. "Gallium trichloride catalyzed hydroamination of alkynes: Scope, limitation, and mechanistic studies by dft". supporting information. p. 5564 - 5572. Retrieved 2012/11/07.