1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine

Base Information

Chemical Name:1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine
CAS No.:250708-46-4
Molecular Formula:C₂₇H₂₇F₄N₃O₆
Molecular Weight:565.521
Hs Code.:

Synonyms:1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine

Suppliers and Price of 1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine

There total 8 articles about 1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 383-63-1
ethyl trifluoroacetate,

: 250708-47-5
1-{5-amino-3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-α-L-lyxofuranosyl}thymine

: 250708-46-4
1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(99)00452-7

Reference yield:

: 250708-33-9
1-{5-azido-3-O-benzyl-4-C-[(benzyloxy)methyl]-5-deoxy-α-L-xylofuranosyl}thymine

: 250708-46-4
1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / DMAP; pyridine / 2 h / 20 °C

2: 37 percent / Bu₄NF; NaOH / tetrahydrofuran / 24 h / 5 °C / Heating

3: 64 percent / H₂ / Lindlar catalyst / ethanol; dioxane / 8 h / 20 °C

4: 89 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

With pyridine; dmap; sodium hydroxide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; Lindlar's catalyst; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1: Condensation / 2: Substitution / 3: Reduction / 4: Acylation;
DOI:10.1002/(SICI)1522-2675(20000119)83:1<128::AID-HLCA128>3.0.CO;2-Q

Reference yield:

: 250708-29-3
1-{5-azido-3-O-benzyl-4-[(benzyloxy)methyl]-5-deoxy-α-L-lyxofuranosyl}-5-methylpyrimidine-2,4-(1H,3H)-dione

: 250708-46-4
1-{3-O-benzyl-4-C-[(benzyloxy)methyl]-2,5-dideoxy-2-fluoro-5-[(trifluoroacetyl)amino]-α-L-lyxofuranosyl}thymine

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 2 h / 20 °C

2: 94 percent / water; NaOH / ethanol / 0.5 h / Heating

3: 77 percent / DMAP; pyridine / 2 h / 20 °C

4: 37 percent / Bu₄NF; NaOH / tetrahydrofuran / 24 h / 5 °C / Heating

5: 64 percent / H₂ / Lindlar catalyst / ethanol; dioxane / 8 h / 20 °C

6: 89 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

With pyridine; dmap; sodium hydroxide; tetrabutyl ammonium fluoride; water; hydrogen; triethylamine; Lindlar's catalyst; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1: mesylation / 2: Hydrolysis / 3: Condensation / 4: Substitution / 5: Reduction / 6: Acylation;
DOI:10.1002/(SICI)1522-2675(20000119)83:1<128::AID-HLCA128>3.0.CO;2-Q