2-(4-Chlorophenyl)-3-trifluoromethylpyrrole

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-3-trifluoromethylpyrrole
• CAS No.: 157735-83-6
• Molecular Formula: C₁₁H₇ClF₃N
• Molecular Weight: 245.631
• Mol file: 157735-83-6.mol

Synonyms:2-(4-Chlorophenyl)-3-trifluoromethylpyrrole

Chemical Property of 2-(4-Chlorophenyl)-3-trifluoromethylpyrrole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-Chlorophenyl)-3-trifluoromethylpyrrole

There total 1 articles about 2-(4-Chlorophenyl)-3-trifluoromethylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-N-trimethylsilanylmethyl-thiobenzamide → 2-(4-Chlorophenyl)-3-trifluoromethylpyrrole (157735-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 16 h / 20 °C

2: 29 percent / H₂O / hexamethylphosphoric acid triamide / 36 h / 20 - 110 °C

With water; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1: Methylation / 2: Cyclization;

DOI:10.1002/ps.2780410312

Reference yield: 57.0%

isocyanate de chlorosulfonyle (1189-71-5) + 2-(4-Chlorophenyl)-3-trifluoromethylpyrrole (157735-83-6) → 5-(4-Chlorophenyl)-4-trifluoromethylpyrrole-2-carbonitrile (157735-84-7)

Guidance literature:

isocyanate de chlorosulfonyle; 2-(4-Chlorophenyl)-3-trifluoromethylpyrrole; In acetonitrile; at 20 ℃; for 3h;

With N,N-dimethyl-formamide; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1002/ps.2780410312

Reference yield:

2-(4-Chlorophenyl)-3-trifluoromethylpyrrole (157735-83-6) → 3-Bromo-5-(4-chlorophenyl)-4-trifluoromethylpyrrole-2-carbonitrile

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 3 h / 20 °C

1.2: 57 percent / DMF / acetonitrile / 18 h / 20 °C

2.1: 34 percent / NBS / tetrahydrofuran / 36 h / 20 °C

With N-Bromosuccinimide; In tetrahydrofuran; acetonitrile; 1.1: Substitution / 1.2: Rearrangement / 2.1: Bromination;

DOI:10.1002/ps.2780410312

Downstream raw materials:

5-(4-Chlorophenyl)-4-trifluoromethylpyrrole-2-carbonitrile