1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide

Base Information

Chemical Name:1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide
CAS No.:878232-24-7
Molecular Formula:C₂₈H₃₅N₃O₄
Molecular Weight:477.604
Hs Code.:

Synonyms:1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide

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Chemical Property of 1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide

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Technology Process of 1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide

There total 3 articles about 1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

: 6404-31-5
Z-D-proline

: 252002-17-8
3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropane-1-amine

: 878232-24-7
1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide

Guidance literature:: Z-D-proline; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; at 20 ℃; for 0.0833333h;

3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropane-1-amine; In chloroform; at 20 ℃; for 0.5h;
DOI:10.1021/jm0509851

Reference yield:

: 475152-12-6
2-(3-spiro[isobenzofuran-1(3H),4'-piperidine-1-yl]propyl)-1H-indole-1,3(2H)-dione

: 878232-24-7
1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85.8 percent / hydrazine monohydrate / ethanol; CHCl₃ / 1 h / Heating

2.1: HOBT; WSC / CHCl₃ / 0.08 h / 20 °C

2.2: 83.2 percent / CHCl₃ / 0.5 h / 20 °C

With benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; chloroform;
DOI:10.1021/jm0509851

Reference yield:

: 38309-60-3
3H-spiro[2-benzofuran-1,4'-piperidine]

: 878232-24-7
1-benzyloxycarbonyl-N-[3-spiro[isobenzofuran-1(3H),4'-piperidine]-1-ylpropyl]-D-prolineamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 79 percent / potassium carbonate / dimethylformamide / 1 h / 60 °C

2.1: 85.8 percent / hydrazine monohydrate / ethanol; CHCl₃ / 1 h / Heating

3.1: HOBT; WSC / CHCl₃ / 0.08 h / 20 °C

3.2: 83.2 percent / CHCl₃ / 0.5 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0509851