1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine

Base Information

• Chemical Name: 1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine
• CAS No.: 423756-21-2
• Molecular Formula: C₄₆H₆₄F₈N₉O₁₀P
• Molecular Weight: 1086.03
• Mol file: 423756-21-2.mol

Synonyms:1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine

Chemical Property of 1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine

There total 1 articles about 1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

L-α-glycero-3-phosphorylcholine cadmium chloride complex + 12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoic acid (254968-74-6) → 1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine (423756-21-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; benzene; at 20 ℃; for 40h;

DOI:10.1021/jm011032f

Reference yield: 73.0%

1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine (423756-21-2) → 1,2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-2-lyso-sn-glycero-3-phosphocholine (423756-22-3)

Guidance literature:

With phospholipase A₂; In methanol; at 38 ℃;

DOI:10.1021/jm011032f

Reference yield:

1,2-O-di[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-sn-glycero-3-phosphocholine (423756-21-2) → 1-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-2-oleoyl-sn-glycero-3-phosphoate

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / phospholipase A₂ / methanol; various solvent(s) / 38 °C

2: 94 percent / benzene; CHCl₃ / 5 h / 20 °C

3: 61 percent / CH₃COONa; CaCl₂; phospholipase D / diethyl ether / 30 - 35 °C / sonication

With sodium acetate; calcium chloride; phospholipase A₂; phospholipase D; In methanol; diethyl ether; chloroform; benzene;

DOI:10.1021/jm011032f

upstream raw materials:

12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]amidododecanoic acid

Downstream raw materials:

1,2-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-2-lyso-sn-glycero-3-phosphocholine

1-O-[12-[N-(4-azido-2,3,5,6-tetrafluorobenzoyl)]aminododecanoyl]-2-oleoyl-sn-glycero-3-phosphocholine