t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate

Base Information

• Chemical Name: t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate
• CAS No.: 738606-87-6
• Molecular Formula: C₃₃H₄₉NO₆S
• Molecular Weight: 587.821
• Mol file: 738606-87-6.mol

Synonyms:t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate

Chemical Property of t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate

There total 3 articles about t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl 1-(4-bromobutyl)-1-cyclopropanecarboxylate (738606-85-4) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate (738606-87-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 2.16667h;

DOI:10.1016/j.bmc.2004.09.046

Reference yield:

tert-butyl cyclopropanecarboxylate (87661-20-9) → t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate (738606-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 6.5 h / -60 - 20 °C

2: 10.00 g / NaH; Bu₄NI / dimethylsulfoxide; various solvent(s) / 2.17 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2004.09.046

Reference yield:

t-butyl 1-(4-bromobutyl)-1-cyclopropanecarboxylate (738606-85-4) → t-butyl 1-{9-[1-(t-butoxycarbonyl)cyclopropyl]-5-isocyano-5-[(4-methylphenyl)sulfonyl]nonyl}-1-cyclopropanecarboxylate (738606-87-6)

Guidance literature:

With [(p-methylphenyl)sulfonylmethyl]isonitrile; tetra-(n-butyl)ammonium iodide; sodium hydride; In dimethyl sulfoxide; for 0.166667h; Under N₂ atmosphere; Cooling water bath;

t-butyl 1-(4-bromobutyl)-1-cyclopropanecarboxylate; for 2.16667h;

upstream raw materials:

t-butyl 1-(4-bromobutyl)-1-cyclopropanecarboxylate

[(p-methylphenyl)sulfonylmethyl]isonitrile

tert-butyl cyclopropanecarboxylate