ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

Base Information

Chemical Name:ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate
CAS No.:1198181-47-3
Molecular Formula:C₁₆H₁₂F₄O₃
Molecular Weight:328.263
Hs Code.:

Synonyms:ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

Chemical Property:

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Technology Process of ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

There total 2 articles about ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: (2-fluoro-3-(trifluoromethyl)phenyl)boronic acid

: 50527-72-5
3-(5-bromo-furan-2-yl)-acrylic acid ethyl ester

: 1198181-47-3
ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ISOPROPYLAMIDE; for 16h; Inert atmosphere;

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1198181-47-3
ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE / 16 h / Inert atmosphere

With sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ISOPROPYLAMIDE; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1198181-47-3
ethyl (2E)-3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enoate

: 1198180-58-3
3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 26 h / 20 °C

2.1: water; lithium hydroxide / ethanol / 2 h / 20 °C

2.2: pH 2

With water; hydrogen; lithium hydroxide; palladium 10% on activated carbon; In methanol; ethanol;