3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

Base Information

Chemical Name:3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid
CAS No.:1198180-58-3
Molecular Formula:C₁₄H₁₄F₄O₃
Molecular Weight:306.257
Hs Code.:

Synonyms:3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

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Chemical Property of 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

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Technology Process of 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

There total 4 articles about 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1198181-48-4
ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate

: 1198180-58-3
3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

Guidance literature:: ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate; With water; lithium hydroxide; In ethanol; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1198180-58-3
3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE / 16 h / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 26 h / 20 °C

4.1: water; lithium hydroxide / ethanol / 2 h / 20 °C

4.2: pH 2

With water; hydrogen; sodium hydride; sodium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 50527-72-5
3-(5-bromo-furan-2-yl)-acrylic acid ethyl ester

: 1198180-58-3
3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE / 16 h / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 26 h / 20 °C

3.1: water; lithium hydroxide / ethanol / 2 h / 20 °C

3.2: pH 2

With water; hydrogen; sodium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; ISOPROPYLAMIDE;