1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline

Base Information

Chemical Name:1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline
CAS No.:83551-92-2
Molecular Formula:C₂₆H₃₂N₂O₅S
Molecular Weight:484.616
Hs Code.:

Synonyms:1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline

Chemical Property:

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Technology Process of 1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline

There total 8 articles about 1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 113949-54-5
C₂₉H₄₀N₂O₅SSi

: 83551-92-2
1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline

Guidance literature:: With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; for 15h;
DOI:10.1021/jm00401a014

Reference yield:

: 81653-77-2
(S)-4-phenylthio-L-proline

: 83551-92-2
1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / Et₃N / H₂O; acetone / 24 h

2: 81 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 3 h

3: 59 percent / p-TsOH / acetonitrile / 1.75 h / Heating

4: 70 percent / DCC, 1-hydroxybenzotriazole hydrate, diisopropylethylamine / tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) room temperature, 18 h

5: 79 percent / tetrabutylammonium fluoride trihydrate / dimethylformamide / 15 h

With dmap; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; 1-hydroxybenzotriazol-hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00401a014