(2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane

Base Information

Chemical Name:(2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane
CAS No.:960595-99-7
Molecular Formula:C₁₈H₃₂N₂O₆SSi
Molecular Weight:432.613
Hs Code.:

Synonyms:(2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane

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Technology Process of (2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane

There total 4 articles about (2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 960595-98-6
(2R,3R)-3-methyl-2-(2-nitrobenzenesulfonylamino)pentane-1,3-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 960595-99-7
(2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane

Guidance literature:: With triethylamine; dmap; In dichloromethane; at 0 - 20 ℃; for 48.3h;
DOI:10.1021/ja0758077

Reference yield:

: 870137-18-1
(R)-4-((R)-1-hydroxy-1-methylprop-2-ynyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 960595-99-7
(2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium on activated charcoal / ethanol

2: hydrogenchloride; water / tetrahydrofuran

3: sodium carbonate / tetrahydrofuran; water / 20 °C

4: triethylamine; dmap / dichloromethane / 20 °C

With hydrogenchloride; dmap; palladium on activated charcoal; water; hydrogen; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.tetasy.2013.08.009

Reference yield:

: C₆H₁₅NO₂

: 960595-99-7
(2R,3R)-tert-butyldimethyl-[3-methyl-3-hydroxy-2-(2-nitrobenzenesulfonylamino)]pentoxysilane

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran; water / 20 °C

2: triethylamine; dmap / dichloromethane / 20 °C

With dmap; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetasy.2013.08.009